msem-instigator

As an additional cost to cast this spell, sacrifice a creature.
Destroy target creature.

As an additional cost to cast this spell, torment yourself. (You lose 3 life unless you discard a card or sacrifice a nonland permanent.)
Destroy target creature.

Destroy target creature, enchantment, or planeswalker. Its controller draws a card unless a creature died under your control this turn.

[+2]: Up to one target creature gets -1/-1 until your next turn. Tap it. You may remove all counters from it.
[–2]: Destroy target creature with no counters on it.
[–10]: Each opponent's life total becomes equal to the number of creatures they control.

Destroy target creature with mana value X or less.

Destroy target creature with mana value 2 or less. If it was a token, you gain 2 life.

Destroy target creature. Then if there are ten or more cards in your graveyard, return target creature card from your graveyard to your hand.

Until end of turn, target creature you control gains “{T}: Destroy target creature.”

(As this Saga enters and after your draw step, add a lore counter. Sacrifice after III.)
I — Destroy target creature you don't control with the greatest power.
II — Until your next turn, prevent all damage that would be dealt to you and planeswalkers you control.
III — Exile target card from a graveyard. You gain 2 life.

At the beginning of your upkeep, destroy target creature with the greatest power or tied for greatest power among creatures on the battlefield. Then if there are no creatures on the battlefield, sacrifice The Empty Throne.

Return target creature card from your graveyard to the battlefield, then destroy target creature an opponent controls that doesn't share a creature type with it.

Destroy target creature with power less than or equal to the number of creature cards in your graveyard.

Destroy target creature with no counters on it and no permanents attached to it.

Destroy target creature. Mill a number of cards equal to its power.

Destroy target creature or planeswalker you don't control. Its controller creates two tapped Treasure tokens.

Destroy target creature with power, toughness, or mana value 4 or greater.

Destroy target creature with power or toughness 2 or less.

Enchant land you control
Whenever enchanted land is tapped for mana, it produces an additional mana of that type.
{1}{G}, Sacrifice Under Untamed Skies: Destroy target creature with flying.

Flying
When Unfettered Atrocity enters, destroy target creature or planeswalker.

Destroy target creature with total power and toughness 8 or less.

Glitch—Sacrifice a creature. (Remove one [restriction] for each time you pay the glitch cost.)
When Unshackled Revolutionary enters, you may destroy target creature an opponent controls [with mana value 3 or less]. [You lose 3 life.]

All creatures have “When this creature enters, destroy target creature with a lesser mana value.”

Foretell {B} (During your turn, you may pay {2} and exile this card from your hand face down. Cast it on a later turn for its foretell cost.)
Destroy target creature or planeswalker. You lose 4 life unless this spell was foretold.

Choose one —
• Target creature gains indestructible until end of turn.
• Destroy target creature with toughness 4 or greater.

Deathtouch
Menagerie — When Venomfrill Familiar enters, if there are five or more creature types among creatures you control, you may destroy target creature or planeswalker.