msem-instigator

As Unlikely Growth enters, choose grow or maintain.
Whenever a land you control enters,
• Grow — Put a +1/+1 counter on target creature you control.
• Maintain — Target creature you control gains trample and indestructible until end of turn.

{T}, Pay 1 life: Add {U} or {B}.
{1}, {T}, Sacrifice Unlit Alley: Investigate. (Create a colorless Clue artifact token with “{2}, Sacrifice this artifact: Draw a card.”)

Flying
Whenever you cast a spell from your graveyard, return Unliving Swarm from your graveyard to your hand.

When Unmarked Vials enters, create a Vial token. (It's an artifact with “{1}, Sacrifice this and another permanent: Draw a card. Activate only during your turn.”)
{1}, {T}: Add one mana of any color.

When Unmasker of Fate's Design enters, look at target player's hand. Choose a nonland card from it and exile that card with a puzzle counter on it. As long as that card has a puzzle counter on it, that player may pay {2} and 1 life at any time. If they do, return the exiled card to their hand.

{6}{W}: Tap all creatures target player controls.

Menace
Foresight — Whenever you draw your second card each turn, target player loses 2 life and you gain 2 life.

Whenever a creature dies, you may put a progress counter on Unorthodox Methods.
[progress 2-6] Whenever you cast a noncreature spell, Unorthodox Methods deals 2 damage to any target and you gain 2 life.
[progress 7+] Whenever you cast a noncreature spell, Unorthodox Methods deals 4 damage to any target and you gain 4 life.
Whenever you cast a noncreature spell, CARDNAME deals 4 damage to any target and you gain 4 life.

At the beginning of your upkeep, each player mills two cards, then reveals the top card of their library and puts it on the bottom of their library.

Trample
Defiance (Whenever this creature takes damage, if it survives and wasn't defiant, put a +1/+1 counter on it and it becomes defiant.)

Flying
When Unraveller of Mysteries enters, mill two cards.

Unreflected Cultist can't be blocked by Reflections.

Trample, ward {1}
Whenever you gain life, put a +1/+1 counter on Unrelenting Noble.
{1}, Sacrifice a permanent: You gain 2 life.

This spell costs {2} less to cast if your starting deck contained at least forty cards more than the minimum deck size.
When Unrivaled Fireweaver enters, you may exile a red instant or sorcery card you own from outside the game. Until the end of your next turn, you may play that card.

Trample
Whenever Unruly Cannoneer crews a Vehicle, that Vehicle gets +1/+1 and gains trample until end of turn.

Haste
Prowess (Whenever you cast a noncreature spell, this creature gets +1/+1 until end of turn.)
Whenever Unruly Magus deals combat damage to a player, draw a card.

Prowess
Whenever Unseen Hand attacks, exile target noncreature, nonland card with mana value 1 or less from your graveyard. Copy that card. You may cast the copy. (You still pay its costs.)

Discard a card: Unseen Maniac gets +1/+1 and can't be blocked this turn.
Whenever Unseen Maniac deals combat damage to a player, draw a card.

Glitch—Sacrifice a creature. (Remove one [restriction] for each time you pay the glitch cost.)
When Unshackled Revolutionary enters, you may destroy target creature an opponent controls [with mana value 3 or less]. [You lose 3 life.]

Trample (This creature can deal excess combat damage to the player or planeswalker it's attacking.)
Unstable Borer attacks each combat if able.

Vanishing 2 (This permanent enters with two time counters on it. At the beginning of your upkeep, remove a time counter from it. When the last is removed, sacrifice it.)
{T}: Add {C}.
When Unstable Footing is put into your graveyard from the battlefield, if it had no time counters on it, search your library for a basic land card, put it onto the battlefield, then shuffle.

You may have Unstable Impersonator enter as a copy of any creature on the battlefield chosen at random.

Vanishing 5 (This creature enters with five time counters on it. At the beginning of your upkeep, remove a time counter from it. When the last is removed, sacrifice it.)
{1}{R}, Remove a time counter from Unstable Magmaling: Flip a coin. If you win the flip, it deals 3 damage to any target.

When Unstable Orb enters, draw a card.
{3}, {T}, Sacrifice Unstable Orb: It deals 2 damage to target creature.

Rhapsody {4}{U}{U} (Pay {4}{U}{U} to cast this as a 4/4, or as a sorcery to make it become a 4/4.)
When Unstable Prophet enters, surveil X, where X is its power. (Look at the top X cards of your library, then put any number of them into your graveyard and the rest on top of your library in any order.)