msem-instigator

Destroy target creature with flying.
Draw a card.

Destroy target creature. Its controller discards a card.

Destroy target creature. You gain 1 life for each card in its controller's graveyard.

As an additional cost to cast this spell, sacrifice a creature or planeswalker.
Destroy target creature or planeswalker.

Flash
When Charnel Legion enters the battlefield, destroy target creature or planeswalker an opponent controls that was dealt damage this turn. When you do, you gain 2 life.

Destroy target creature with flying. If that creature had power 4 or greater, you gain 4 life.

Bleed {2}{B} (You may cast this spell for its bleed cost if an opponent has lost life this turn.)
Destroy target creature. Its controller loses 2 life.

Destroy target creature. (Cast a copy of this spell once while this creature is on the battlefield.)

Golden age (If you cast an instant or sorcery spell, activated a nonmana ability, and attacked this turn, enter a renaissance for this game.)
Destroy target creature. If you're in a renaissance, you may return a creature card from your graveyard to your hand.

Whenever another enchantment enters the battlefield under your control, you may put a progress counter on Corporate War.
[PROGRESS 2-5] {W}{B}, Sacrifice a creature or enchantment: Destroy target creature or enchantment.
[PROGRESS 6+] Sacrifice a creature or enchantment: Destroy target permanent.

Flying
{1}{B}, {T}: Destroy target creature that was dealt damage this turn.

Destroy target creature.
Create a Vial token. (It's an artifact with “{1}, Sacrifice this and another permanent: Draw a card. Activate only during your turn.”)

Escalate {2} (Pay this cost for each mode chosen beyond the first.)
Choose one or more —
• Counter target spell.
• Destroy target creature.
• Discard your hand, then draw two cards.

Escalate {B}{B} (Pay this cost for each mode chosen beyond the first.)
Choose one or more. You may choose the same mode more than once.
• Destroy target creature.
• Target player draws two cards and loses 2 life.

Enchant player
When Curse of Life's Cycles enters the battlefield, destroy target creature enchanted player controls.
Concord — At the beginning of enchanted player's upkeep, if there are four or more card types among permanents you control, that player loses 1 life and you gain 1 life.

Deathtouch (Any amount of damage this deals to a creature is enough to destroy it.)
Whenever a creature an opponent controls dies, its controller discards a card and loses 1 life.
{1}{B}{B}, {T}, Sacrifice another creature: Destroy target creature.

Augmented — When Dead End Adventurer enters the battlefield, if you've spent {W}{U}{B}{R}{G} to cast spells this turn, destroy target creature you don't control.

Destroy target creature. You may put a -1/-1 counter on target creature.

Destroy target creature that's not enchanted and isn't an enchantment.

Destroy target creature or planeswalker.
Compose (Then if you cast this from your hand, exile it and create a Saga token with “III—You may cast a copy of this card from exile without paying its mana cost.”)

When Deliver from Dilapidation enters the battlefield, you may sacrifice any number of enchantments. Whenever you sacrifice an enchantment this way, destroy target creature.
At the beginning of your upkeep, return target enchantment card with mana value 5 or less from your graveyard to the battlefield.

Destroy target creature if it has the least power or is tied for least power among creatures on the battlefield.
Memento {3}{B}{B} (You may cast this from your graveyard for {3}{B}{B}. If you do, put it onto the battlefield transformed after it resolves. Exile it if it would leave the battlefield or not resolve.)

Destroy target creature.

Destroy target creature or planeswalker. Draw a card.

Destroy target creature that isn't in a pack. (Two or more creatures a player controls with equal power are in a pack.)